Translational control of SEPT9 isoforms is perturbed in disease

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Translational control of SEPT9 isoforms is perturbed in disease.

A common feature of the mammalian septin gene family is complex genomic architecture with multiple alternate splice variants. Septin 9 has 18 distinct transcripts encoding 15 polypeptides, with two transcripts (SEPT9_v4 and v4*) encoding the same polypeptide. We have previously reported that the ratio of these distinct transcripts is altered in neoplasia, with the v4 transcript being the usual ...

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ژورنال

عنوان ژورنال: Human Molecular Genetics

سال: 2007

ISSN: 1460-2083,0964-6906

DOI: 10.1093/hmg/ddm003